Pragmatic Apparatus – Virtual Gene Concept and a Corresponding Pragmatic Research Program in Genetical Data Science

Cited by Lee Sonogan

Learn about data in precision medicine | Precision medicine, Supervised machine  learning, Gene expression

Abstract by Łukasz Huminiecki

Mendel proposed an experimentally verifiable paradigm of particle-based heredity that has been influential for over 150 years. The historical arguments have been reflected in the near past as Mendel’s concept has been diversified by new types of omics data. As an effect of the accumulation of omics data, a virtual gene concept forms, giving rise to genetical data science. The concept integrates genetical, functional, and molecular features of the Mendelian paradigm. I argue that the virtual gene concept should be deployed pragmatically. Indeed, the concept has already inspired a practical research program related to systems genetics. The program includes questions about functionality of structural and categorical gene variants, about regulation of gene expression, and about roles of epigenetic modifications. The methodology of the program includes bioinformatics, machine learning, and deep learning. Education, funding, careers, standards, benchmarks, and tools to monitor research progress should be provided to support the research program.

Publication: Evolutionary, Computational, and Statistical Genetics, Department of Molecula Biology, Institute of Genetics and Animal Biotechnology, Polish Academy of Sciences, Postępu 36A, Jastrzębiec, 05-552 Warsaw, Poland (Peer-Reviewed Journal)

Pub Date: 23 Dec, 2021 Doi: https://doi.org/10.3390/e24010017

Keywords: gene concept; technology; scientific method; experimentalism; molecular biology; genomics; bioinformatics; computational biology; data science; virtualization

https://www.mdpi.com/1099-4300/24/1/17/htm (Plenty more sections and references in this research article)(

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